ACER1
alkaline ceramidase 1
Synonyms:
ALKCDase1, ASAH3
Species:
Human ACER1 (125981), Mouse Acer1 (171168), Rat Acer1 (301118), naked mole-rat Acer1 (101702052), domestic cat ACER1 (101095079), Zebrafish acer1 (550266), chicken ACER1 (420088), sheep ACER1 (101106585), domestic guinea pig Acer1 (100718251), dog ACER1 (611739)
UniProtKB ID:
Gene ID:
- Human(125981) Summary: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]
- Mouse(171168) alkaline ceramidase 1
- Rat(301118) alkaline ceramidase 1
- naked mole-rat(101702052) alkaline ceramidase 1
- domestic cat(101095079) alkaline ceramidase 1
- Zebrafish(550266) alkaline ceramidase 1
- chicken(420088) alkaline ceramidase 1
- sheep(101106585) alkaline ceramidase 1
- domestic guinea pig(100718251) alkaline ceramidase 1
- dog(611739) alkaline ceramidase 1
- cow(518021) alkaline ceramidase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ACER1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot