ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
Synonyms:
ADAMTS-2, ADAMTS-4, ADMP-1
Species:
Human ADAMTS4 (9507), Mouse Adamts4 (240913), Rat Adamts4 (66015), domestic cat ADAMTS4 (101089488), Horse ADAMTS4 (100033914), dog ADAMTS4 (488651), sheep ADAMTS4 (101106565), cow ADAMTS4 (286806), naked mole-rat Adamts4 (101702362), domestic guinea pig Adamts4 (100712995)
UniProtKB ID:
Gene ID:
- Human(9507) Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
- Mouse(240913) a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
- Rat(66015) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- domestic cat(101089488) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- Horse(100033914) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- dog(488651) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- sheep(101106565) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- cow(286806) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- naked mole-rat(101702362) ADAM metallopeptidase with thrombospondin type 1 motif, 4
- domestic guinea pig(100712995) ADAM metallopeptidase with thrombospondin type 1 motif, 4
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ELISA
Product Number
Description
Species
Human ADAMTS4 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ADAMTS4 antibody produced in mouse, clone 2A6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
immunoprecipitation (IP)
Anti-ADAMTS4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-ADAMTS4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-ADAMTS4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-ADAMTS4, affinity isolated antibody,
Species Reactivity
bovine, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
ADAMTS-4, recombinant, His Tagged, This His Tagged Recombinant ADAMTS4 is used to study the degradation of extracellular matrix proteoglycans, to screen for inhibitors of proteoglycan hydrolysis and to characterize inhibitor actions.,
Species
human