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MilliporeSigma

CARD8

caspase recruitment domain family, member 8

Synonyms:
CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
Species:
Human CARD8 (22900), dog CARD8 (491519), domestic cat CARD8 (101093817), chicken CARD8 (416998)
UniProtKB ID:
Q9Y2G2, B5KVR6, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
Gene ID:
  • Human(22900) Summary: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
  • dog(491519) caspase recruitment domain family, member 8
  • domestic cat(101093817) caspase recruitment domain family, member 8
  • chicken(416998) caspase recruitment domain family, member 8

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
PRS3187
Anti-CARD8 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunocytochemistry
immunofluorescence
western blot
SAB2900363
Anti-CARD8 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
HPA042071
Anti-CARD8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
SAB1410395
Anti-CARD8 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
ZRB2636
Anti-CARD8 Antibody, clone 1C23 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
EHU070091
MISSION® esiRNA, targeting human CARD8,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
A4188
N-Acetyl-Ile-Glu-Thr-Asp-7-Amido-4-methylcoumarin, ≥97% (HPLC), powder,
Species
rat, mouse, human
A6470
N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide, ≥97% (HPLC), powder,
Species
rat, mouse, human
A9968
N-Acetyl-Ile-Glu-Thr-Asp-p-nitroanilide, ≥95%,
Species
rat, mouse, human
A6220
N-Acetyl-Ile-Glu-Pro-Asp-7-amido-4-methylcoumarin, ≥97% (HPLC), powder,
Species
rat, mouse, human