CASP12
caspase 12 (gene/pseudogene)
Synonyms:
CASP-12, CASP12P1
Species:
Human CASP12 (100506742), Mouse Casp12 (12364), Rat Casp12 (156117), dog CASP12 (479458), domestic cat CASP12 (100135767)
UniProtKB ID:
Gene ID:
- Human(100506742) Summary: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
- Mouse(12364) caspase 12
- Rat(156117) caspase 12
- dog(479458) caspase 12
- domestic cat(100135767) caspase 12
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CASPASE-12 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase-12 (small) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase-12 (large) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-Caspase 12 antibody produced in rat, clone 14F7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
Anti-Caspase 12 Antibody, NT, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot