CCM2
cerebral cavernous malformation 2
Synonyms:
C7orf22, OSM
Species:
Human CCM2 (83605), Mouse Ccm2 (216527), Rat Ccm2 (305505), Zebrafish ccm2 (436586), naked mole-rat Ccm2 (101711971), domestic guinea pig Ccm2 (100716240), sheep CCM2 (101114100), cow CCM2 (506450), Horse CCM2 (100065340), domestic cat CCM2 (101100375) ...More
UniProtKB ID:
Gene ID:
- Human(83605) Summary: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
- Mouse(216527) cerebral cavernous malformation 2
- Rat(305505) cerebral cavernous malformation 2
- Zebrafish(436586) cerebral cavernous malformation 2
- naked mole-rat(101711971) cerebral cavernous malformation 2
- domestic guinea pig(100716240) cerebral cavernous malformation 2
- sheep(101114100) cerebral cavernous malformation 2
- cow(506450) cerebral cavernous malformation 2
- Horse(100065340) cerebral cavernous malformation 2
- domestic cat(101100375) cerebral cavernous malformation 2
- dog(475502) cerebral cavernous malformation 2
- chicken(420410) cerebral cavernous malformation 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CCM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunohistochemistry
Anti-CCM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-CCM2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-CCM2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-CCM2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
western blot