CFB
complement factor B
Synonyms:
AHUS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Species:
Human CFB (629), Mouse Cfb (14962), Rat Cfb (294257), cow CFB (514076), Horse CFB (100051124), dog CFB (100688056), sheep CFB (101115072), Zebrafish cfb (30604), domestic cat CFB (101093018), naked mole-rat Cfb (101725137)
UniProtKB ID:
Gene ID:
- Human(629) Summary: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
- Mouse(14962) complement factor B
- Rat(294257) complement factor B
- cow(514076) complement factor B
- Horse(100051124) complement factor B
- dog(100688056) complement factor B
- sheep(101115072) complement factor B
- Zebrafish(30604) complement factor B
- domestic cat(101093018) complement factor B
- naked mole-rat(101725137) complement factor B
- domestic guinea pig(100715616) complement factor B
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CFAB Bb (Cleaved-Lys260) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
western blot
Anti-CFB antibody produced in rabbit, Ab3, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
ANTI-CFB antibody produced in rabbit, Ab4, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
esiRNA
Product Number
Description
Species