CFI
complement factor I
Synonyms:
AHUS3, C3BINA, C3b-INA, FI, IF, KAF
Species:
Human CFI (3426), Mouse Cfi (12630), Rat Cfi (79126), chicken CFI (428773), Zebrafish cfi (557557), domestic cat CFI (101086649), dog CFI (478515), Domestic Rabbit CFI (100338923), sheep CFI (101119307), cow CFI (513197) ...More
UniProtKB ID:
Gene ID:
- Human(3426) Summary: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008]
- Mouse(12630) complement component factor i
- Rat(79126) complement factor I
- chicken(428773) complement factor I
- Zebrafish(557557) complement factor I
- domestic cat(101086649) complement factor I
- dog(478515) complement factor I
- Domestic Rabbit(100338923) complement factor I
- sheep(101119307) complement factor I
- cow(513197) complement factor I
- Horse(100072852) complement factor I
- naked mole-rat(101705881) complement factor I
- domestic guinea pig(100713918) complement factor I
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CFI antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-CFI antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-CFI antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Proteins
Product Number
Description
Species
esiRNA
Product Number
Description
Species