CIITA
class II, major histocompatibility complex, transactivator
Synonyms:
C2TA, CIITAIV, MHC2TA, NLRA
Species:
Human CIITA (4261), Mouse Ciita (12265), Rat Ciita (85483), Zebrafish ciita (100003537), chicken CIITA (427676), dog CIITA (490008), sheep CIITA (101106564), domestic guinea pig Ciita (100726338), Horse CIITA (100056546), Domestic Rabbit CIITA (100338894) ...More
UniProtKB ID:
Gene ID:
- Human(4261) Summary: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]
- Mouse(12265) class II transactivator
- Rat(85483) class II, major histocompatibility complex, transactivator
- Zebrafish(100003537) class II, major histocompatibility complex, transactivator
- chicken(427676) class II, major histocompatibility complex, transactivator
- dog(490008) class II, major histocompatibility complex, transactivator
- sheep(101106564) class II, major histocompatibility complex, transactivator
- domestic guinea pig(100726338) class II, major histocompatibility complex, transactivator
- Horse(100056546) class II, major histocompatibility complex, transactivator
- Domestic Rabbit(100338894) class II, major histocompatibility complex, transactivator
- naked mole-rat(101721690) class II, major histocompatibility complex, transactivator
- cow(508720) class II, major histocompatibility complex, transactivator
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CIITA Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Anti-CIITA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-CIITA antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-CIITA antibody, Mouse monoclonal, clone 7-1H, purified from hybridoma cell culture,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
western blot