DCLK1
doublecortin-like kinase 1
Synonyms:
CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
Species:
Human DCLK1 (9201), Mouse Dclk1 (13175), Rat Dclk1 (83825), naked mole-rat Dclk1 (101719985), cow DCLK1 (613449), chicken DCLK1 (418903), sheep DCLK1 (101106340), Horse DCLK1 (100062396), dog DCLK1 (477304), domestic cat DCLK1 (101083643)
UniProtKB ID:
Gene ID:
- Human(9201) Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
- Mouse(13175) doublecortin-like kinase 1
- Rat(83825) doublecortin-like kinase 1
- naked mole-rat(101719985) doublecortin-like kinase 1
- cow(613449) doublecortin-like kinase 1
- chicken(418903) doublecortin-like kinase 1
- sheep(101106340) doublecortin-like kinase 1
- Horse(100062396) doublecortin-like kinase 1
- dog(477304) doublecortin-like kinase 1
- domestic cat(101083643) doublecortin-like kinase 1
- domestic guinea pig(100725335) doublecortin-like kinase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DCLK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-DCAMKL1, (C-terminal) antibody produced in mouse, clone 6H4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-DCAMKL1 (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DCLK1-S, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-DCLK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence