DDB1
damage-specific DNA binding protein 1, 127kDa
Synonyms:
DDBA, UV-DDB1, XAP1, XPCE, XPE, XPE-BF
Species:
Human DDB1 (1642), Mouse Ddb1 (13194), Rat Ddb1 (64470), naked mole-rat Ddb1 (101712635), Zebrafish ddb1 (393599), Horse DDB1 (100059606), domestic guinea pig Ddb1 (100724177), chicken DDB1 (374050), Domestic Rabbit DDB1 (100354475), dog DDB1 (476067) ...More
UniProtKB ID:
Gene ID:
- Human(1642) Summary: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
- Mouse(13194) damage specific DNA binding protein 1
- Rat(64470) damage-specific DNA binding protein 1, 127kDa
- naked mole-rat(101712635) damage-specific DNA binding protein 1, 127kDa
- Zebrafish(393599) damage specific DNA binding protein 1
- Horse(100059606) damage-specific DNA binding protein 1, 127kDa
- domestic guinea pig(100724177) damage-specific DNA binding protein 1, 127kDa
- chicken(374050) damage-specific DNA binding protein 1, 127kDa
- Domestic Rabbit(100354475) damage-specific DNA binding protein 1, 127kDa
- dog(476067) damage-specific DNA binding protein 1, 127kDa
- sheep(101106122) damage-specific DNA binding protein 1, 127kDa
- domestic cat(101081079) damage-specific DNA binding protein 1, 127kDa
- cow(511951) damage-specific DNA binding protein 1, 127kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Rabbit anti-DDB1 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-DDB1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-DDB1 antibody produced in rabbit, ,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-DDB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-DDB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry