DIO1
deiodinase, iodothyronine, type I
Synonyms:
5DI, TXDI1
Species:
Human DIO1 (1733), Mouse Dio1 (13370), Rat Dio1 (25430), Zebrafish dio1 (799937), Horse DIO1 (100050359), dog DIO1 (403635), cow DIO1 (782446), domestic guinea pig Dio1 (100715950), naked mole-rat Dio1 (101704592), Domestic Rabbit DIO1 (100101570) ...More
UniProtKB ID:
Gene ID:
- Human(1733) Summary: The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence. [provided by RefSeq, Jul 2008]
- Mouse(13370) deiodinase, iodothyronine, type I
- Rat(25430) deiodinase, iodothyronine, type I
- Zebrafish(799937) deiodinase, iodothyronine, type I
- Horse(100050359) deiodinase, iodothyronine, type I
- dog(403635) deiodinase, iodothyronine, type I
- cow(782446) deiodinase, iodothyronine, type I
- domestic guinea pig(100715950) deiodinase, iodothyronine, type I
- naked mole-rat(101704592) deiodinase, iodothyronine, type I
- Domestic Rabbit(100101570) deiodinase, iodothyronine, type I
- chicken(395940) deiodinase, iodothyronine, type I
- domestic cat(493798) deiodinase, iodothyronine, type I
- sheep(100310792) deiodinase, iodothyronine, type I
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DIO1 antibody produced in mouse, clone 1E4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
ANTI-DIO1 (N-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species