FOLH1
folate hydrolase (prostate-specific membrane antigen) 1
Synonyms:
FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
Species:
Human FOLH1 (2346), Mouse Folh1 (53320), Rat Folh1 (85309), chicken FOLH1 (419011), dog FOLH1 (476775), domestic guinea pig Folh1 (100712916), cow FOLH1 (505865), naked mole-rat Folh1 (101725016), Domestic Rabbit FOLH1 (100358060)
UniProtKB ID:
Gene ID:
- Human(2346) Summary: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
- Mouse(53320) folate hydrolase 1
- Rat(85309) folate hydrolase 1
- chicken(419011) folate hydrolase (prostate-specific membrane antigen) 1
- dog(476775) folate hydrolase (prostate-specific membrane antigen) 1
- domestic guinea pig(100712916) folate hydrolase (prostate-specific membrane antigen) 1
- cow(505865) folate hydrolase (prostate-specific membrane antigen) 1
- naked mole-rat(101725016) folate hydrolase (prostate-specific membrane antigen) 1
- Domestic Rabbit(100358060) folate hydrolase (prostate-specific membrane antigen) 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-FOLH1-PE antibody produced in mouse, clone GCP-05, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
Anti-PSMA antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM327, purified immunoglobulin,
Species Reactivity
human
Application
immunohistochemistry
Anti-PSMA antibody, Rabbit monoclonal, clone SP29, recombinant, expressed in proprietary host, tissue culture supernatant,
Species Reactivity
bovine, dog, human, mouse, pig, rat
Application
immunohistochemistry
PSMA (EP192) Rabbit Monoclonal Primary Antibody, ,
Species Reactivity
Application
immunohistochemistry
Monoclonal Anti-FOLH1 antibody produced in mouse, clone GCP-05, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
Small Molecule - Inhibitor
Product Number
Description
Species