FXYD5
FXYD domain containing ion transport regulator 5
Synonyms:
DYSAD, IWU1, KCT1, OIT2, PRO6241, RIC
Species:
Human FXYD5 (53827), Mouse Fxyd5 (18301), Rat Fxyd5 (60338), naked mole-rat Fxyd5 (101707412), cow FXYD5 (505584), sheep FXYD5 (101105940), domestic guinea pig Fxyd5 (100719588), dog FXYD5 (612666)
UniProtKB ID:
Gene ID:
- Human(53827) Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
- Mouse(18301) FXYD domain-containing ion transport regulator 5
- Rat(60338) FXYD domain-containing ion transport regulator 5
- naked mole-rat(101707412) FXYD domain containing ion transport regulator 5
- cow(505584) FXYD domain containing ion transport regulator 5
- sheep(101105940) FXYD domain containing ion transport regulator 5
- domestic guinea pig(100719588) FXYD domain containing ion transport regulator 5
- dog(612666) FXYD domain containing ion transport regulator 5
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-FXYD5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Fxyd5 Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL14037, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-Fxyd5 Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL14039, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-Dysadherin antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot