GNPTAB
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms:
GNPTA, ICD
Species:
Human GNPTAB (79158), Mouse Gnptab (432486), Rat Gnptab (362865), naked mole-rat Gnptab (101710539), Zebrafish gnptab (553365), chicken GNPTAB (418096), domestic cat GNPTAB (101100231), dog GNPTAB (475443), cow GNPTAB (509610), Horse GNPTAB (100067011) ...More
UniProtKB ID:
Gene ID:
- Human(79158) Summary: This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010]
- Mouse(432486) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- Rat(362865) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- naked mole-rat(101710539) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- Zebrafish(553365) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- chicken(418096) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- domestic cat(101100231) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- dog(475443) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- cow(509610) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- Horse(100067011) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- Domestic Rabbit(100340567) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- sheep(101122348) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
- domestic guinea pig(100716394) N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GNPTAB antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot