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IDO1

indoleamine 2,3-dioxygenase 1

Synonyms:
IDO, IDO-1, INDO
Species:
UniProtKB ID:
Gene ID:
  • Human(3620) Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
  • Mouse(15930) indoleamine 2,3-dioxygenase 1
  • Rat(66029) indoleamine 2,3-dioxygenase 1
  • Zebrafish(571967) indoleamine 2,3-dioxygenase 1
  • dog(475574) indoleamine 2,3-dioxygenase 1
  • domestic guinea pig(100728309) indoleamine 2,3-dioxygenase 1
  • naked mole-rat(101723745) indoleamine 2,3-dioxygenase 1
  • domestic cat(101096977) indoleamine 2,3-dioxygenase 1
  • cow(506281) indoleamine 2,3-dioxygenase 1
  • sheep(100196903) indoleamine 2,3-dioxygenase 1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-IDO1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-IDO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-INDO antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-IDO1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
Anti-IDO-1 Antibody, clone 4B7 | MABF850, clone 4B7, from mouse,
Species Reactivity
mouse, rat
Application
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
Mouse IDO1, His-Tag, recombinant, expressed in E. coli,
Species
mouse