KMT2A
lysine (K)-specific methyltransferase 2A
Synonyms:
ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS
Species:
Human KMT2A (4297), Mouse Kmt2a (214162), Rat Kmt2a (315606), cow KMT2A (508330), naked mole-rat Kmt2a (101716671), domestic guinea pig Kmt2a (100727230), Zebrafish kmt2a (557048)
UniProtKB ID:
Gene ID:
- Human(4297) Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
- Mouse(214162) lysine (K)-specific methyltransferase 2A
- Rat(315606) lysine (K)-specific methyltransferase 2A
- cow(508330) lysine (K)-specific methyltransferase 2A
- naked mole-rat(101716671) lysine (K)-specific methyltransferase 2A
- domestic guinea pig(100727230) lysine (K)-specific methyltransferase 2A
- Zebrafish(557048) lysine (K)-specific methyltransferase 2A
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-KMT2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-MLL/HRX Antibody, CT., clone 9-12, clone 9-12, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
ChIP
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Anti-Acetyl MLL1 (KMT2A) (Lys 1130/1133), from rabbit,
Species Reactivity
human, mouse
Application
dot blot
inhibition assay
western blot
inhibition assay
western blot
Anti-MLL/HRX Antibody, NT., clone N4.4, clone N4.4, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
western blot
esiRNA
Product Number
Description
Species