LAMA4
laminin, alpha 4
Synonyms:
CMD1JJ, LAMA3, LAMA4*-1
Species:
Human LAMA4 (3910), Mouse Lama4 (16775), Rat Lama4 (309816), chicken LAMA4 (421749), naked mole-rat Lama4 (101716530), domestic guinea pig Lama4 (100716529), Domestic Rabbit LAMA4 (100352418), sheep LAMA4 (101107969), cow LAMA4 (529670), Horse LAMA4 (100066875) ...More
UniProtKB ID:
Gene ID:
- Human(3910) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
- Mouse(16775) laminin, alpha 4
- Rat(309816) laminin, alpha 4
- chicken(421749) laminin, alpha 4
- naked mole-rat(101716530) laminin, alpha 4
- domestic guinea pig(100716529) laminin, alpha 4
- Domestic Rabbit(100352418) laminin, alpha 4
- sheep(101107969) laminin, alpha 4
- cow(529670) laminin, alpha 4
- Horse(100066875) laminin, alpha 4
- domestic cat(101086907) laminin, alpha 4
- dog(475034) laminin, alpha 4
- Zebrafish(566796) laminin, alpha 4
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-LAMA4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-LAMA4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-LAMA4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-LAMA4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Laminin subunit alpha-4 Antibody, clone 3H2, clone 3H2, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot