MAP2K4
mitogen-activated protein kinase kinase 4
Synonyms:
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Species:
Human MAP2K4 (6416), Mouse Map2k4 (26398), Rat Map2k4 (287398), domestic cat MAP2K4 (101086432), Domestic Rabbit MAP2K4 (100344852), chicken MAP2K4 (417312), dog MAP2K4 (489508), sheep MAP2K4 (101115045), Horse MAP2K4 (100073094), domestic guinea pig Map2k4 (100733674) ...More
UniProtKB ID:
Gene ID:
- Human(6416) Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
- Mouse(26398) mitogen-activated protein kinase kinase 4
- Rat(287398) mitogen activated protein kinase kinase 4
- domestic cat(101086432) mitogen-activated protein kinase kinase 4
- Domestic Rabbit(100344852) mitogen-activated protein kinase kinase 4
- chicken(417312) mitogen-activated protein kinase kinase 4
- dog(489508) mitogen-activated protein kinase kinase 4
- sheep(101115045) mitogen-activated protein kinase kinase 4
- Horse(100073094) mitogen-activated protein kinase kinase 4
- domestic guinea pig(100733674) mitogen-activated protein kinase kinase 4
- naked mole-rat(101705822) mitogen-activated protein kinase kinase 4
- cow(526469) mitogen-activated protein kinase kinase 4
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Phospho-MAP2K4-S257/T261 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunofluorescence
immunohistochemistry
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-JNKK, C-Terminal antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
MKK4/SKK1 Protein, active, 10 µg, Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays.,
Species
mouse
MKK4/SKK1 Protein, inactive, 50 g, Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.,
Species
mouse