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MAP2K7

mitogen-activated protein kinase kinase 7

Synonyms:
Jnkk2, MAPKK7, MKK7, PRKMK7, SAPKK-4, SAPKK4
Species:
UniProtKB ID:
Gene ID:
  • Human(5609) Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008]
  • Mouse(26400) mitogen-activated protein kinase kinase 7
  • Rat(363855) mitogen activated protein kinase kinase 7
  • dog(485004) mitogen-activated protein kinase kinase 7
  • Zebrafish(560913) mitogen-activated protein kinase kinase 7
  • domestic guinea pig(100731057) mitogen-activated protein kinase kinase 7
  • domestic cat(101095157) mitogen-activated protein kinase kinase 7
  • sheep(100302082) mitogen-activated protein kinase kinase 7
  • cow(787278) mitogen-activated protein kinase kinase 7
  • naked mole-rat(101710666) mitogen-activated protein kinase kinase 7

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MKK7/SKK4 Antibody, clone 3F6.5, clone 3F6.5, from mouse,
Species Reactivity
human, mouse
Application
immunocytochemistry
western blot
Anti-MAP2K7 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-phospho-MAP2K7 (pSer271) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-MAP2K7 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-phospho-MKK7/SKK4 (Thr275/Ser277) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
PD 98,059, solid,
Species
human

Proteins

Product Number
Description
Species
MKK7β1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human MKK7β1, amino acids 2-end. For use in Kinase Assays.,
Species
human
MKK7β1 Protein, inactive, 50 g, Unactive, N-terminal GST-tagged, recombinant, human MKK7β1 amino acids 2-end, for use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAP2K7,
Species
human
MISSION® esiRNA, targeting mouse Map2k7,
Species
mouse