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MCM3

minichromosome maintenance complex component 3

Synonyms:
HCC5, P1-MCM3, P1.h, RLFB
Species:
UniProtKB ID:
Gene ID:
  • Human(4172) Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
  • Mouse(17215) minichromosome maintenance deficient 3 (S. cerevisiae)
  • Rat(316273) minichromosome maintenance complex component 3
  • domestic cat(101083515) minichromosome maintenance complex component 3
  • fruit fly(31449) Minichromosome maintenance 3
  • sheep(101104435) minichromosome maintenance complex component 3
  • chicken(422043) minichromosome maintenance complex component 3
  • Horse(100069108) minichromosome maintenance complex component 3
  • dog(481839) minichromosome maintenance complex component 3
  • Domestic Rabbit(100339825) minichromosome maintenance complex component 3
  • naked mole-rat(101719015) minichromosome maintenance complex component 3
  • Zebrafish(100536986) minichromosome maintenance complex component 3
  • Zebrafish(192323) MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
  • cow(281302) minichromosome maintenance complex component 3
  • domestic guinea pig(100729563) minichromosome maintenance complex component 3
  • Thale Cress(834670) DNA replication licensing factor MCM3-like protein

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Antibodies

Product Number
Description
Species Reactivity
Application
ANTI-MCM3 antibody produced in mouse, clone 2A11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Rabbit anti-MCM3 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Species Reactivity
human
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Monoclonal Anti-MCM3, (C-terminal) antibody produced in mouse, clone 3E1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Monoclonal Anti-MCM3 antibody produced in mouse, clone 4F7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunofluorescence

western blot
Anti-MCM3 antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Mcm3,
Species
mouse
MISSION® esiRNA, targeting human MCM3,
Species
human