MSR1
macrophage scavenger receptor 1
Synonyms:
CD204, SCARA1, SR-A, SRA, phSR1, phSR2
Species:
Human MSR1 (4481), Mouse Msr1 (20288), Rat Msr1 (498638), naked mole-rat Msr1 (101712145), domestic guinea pig Msr1 (100731555), dog MSR1 (482891), domestic cat MSR1 (101081290), Horse MSR1 (100053116), cow MSR1 (281311), Domestic Rabbit MSR1 (100009067)
UniProtKB ID:
Gene ID:
- Human(4481) Summary: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
- Mouse(20288) macrophage scavenger receptor 1
- Rat(498638) macrophage scavenger receptor 1
- naked mole-rat(101712145) macrophage scavenger receptor 1
- domestic guinea pig(100731555) macrophage scavenger receptor 1
- dog(482891) macrophage scavenger receptor 1
- domestic cat(101081290) macrophage scavenger receptor 1
- Horse(100053116) macrophage scavenger receptor 1
- cow(281311) macrophage scavenger receptor 1
- Domestic Rabbit(100009067) macrophage scavenger receptor 1
- sheep(101121746) macrophage scavenger receptor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MSR1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-MSR1 antibody produced in mouse, clone 2G8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-MSR1 antibody produced in mouse, clone 2G9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-MSR1 Antibody, clone 10O8B0, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
western blot
Anti-MSR1/CD204 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
flow cytometry
western blot
western blot