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NLRP8

NLR family, pyrin domain containing 8

Synonyms:
CLR19.2, NALP8, NOD16, PAN4
Species:
Human NLRP8 (126205), naked mole-rat Nlrp8 (101718784), cow NLRP8 (506161), dog NLRP8 (611217), domestic cat NLRP8 (101081425)
UniProtKB ID:
Q86W28, Q7RTR4
Gene ID:
  • Human(126205) Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]
  • naked mole-rat(101718784) NLR family, pyrin domain containing 8
  • cow(506161) NLR family, pyrin domain containing 8
  • dog(611217) NLR family, pyrin domain containing 8
  • domestic cat(101081425) NLR family, pyrin domain containing 8

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA056989
Anti-NLRP8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
SAB3500552
Anti-NALP8 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot