NUP98
nucleoporin 98kDa
Synonyms:
ADIR2, NUP196, NUP96
Species:
Human NUP98 (4928), Mouse Nup98 (269966), Rat Nup98 (81738), Horse NUP98 (100052986), chicken NUP98 (430616), domestic cat NUP98 (101086674), dog NUP98 (476822), Zebrafish nup98 (777756), domestic guinea pig Nup98 (100716227), sheep NUP98 (101117360) ...More
UniProtKB ID:
Gene ID:
- Human(4928) Summary: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]
- Mouse(269966) nucleoporin 98
- Rat(81738) nucleoporin 98
- Horse(100052986) nucleoporin 98kDa
- chicken(430616) nucleoporin 98kDa
- domestic cat(101086674) nucleoporin 98kDa
- dog(476822) nucleoporin 98kDa
- Zebrafish(777756) nucleoporin 98
- domestic guinea pig(100716227) nucleoporin 98kDa
- sheep(101117360) nucleoporin 98kDa
- Domestic Rabbit(100343626) nucleoporin 98kDa
- naked mole-rat(101704068) nucleoporin 98kDa
- cow(540004) nucleoporin 98kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Nup96 Antibody, clone 4H5, clone 4H5, from rat,
Species Reactivity
mouse
Application
immunocytochemistry
western blot
western blot
Anti-NUP98 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-NUP98 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, horse, human, rabbit, rat
Application
western blot
Anti-NUP98 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-NUP98 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Cell Lines
Product Number
Description
Species