NXF1
nuclear RNA export factor 1
Synonyms:
MEX67, TAP
Species:
Human NXF1 (10482), Mouse Nxf1 (53319), Rat Nxf1 (59087), naked mole-rat Nxf1 (101699957), domestic guinea pig Nxf1 (100728879), sheep NXF1 (101115327), dog NXF1 (483780), domestic cat NXF1 (101092292), Zebrafish nxf1 (323865), chicken NXF1 (769691) ...More
UniProtKB ID:
Gene ID:
- Human(10482) Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
- Mouse(53319) nuclear RNA export factor 1
- Rat(59087) nuclear RNA export factor 1
- naked mole-rat(101699957) nuclear RNA export factor 1
- domestic guinea pig(100728879) nuclear RNA export factor 1
- sheep(101115327) nuclear RNA export factor 1
- dog(483780) nuclear RNA export factor 1
- domestic cat(101092292) nuclear RNA export factor 1
- Zebrafish(323865) nuclear RNA export factor 1
- chicken(769691) nuclear RNA export factor 1
- Horse(100049009) nuclear RNA export factor 1
- Domestic Rabbit(100347351) nuclear RNA export factor 1
- cow(512136) nuclear RNA export factor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-NXF1 Antibody, serum, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-NXF1 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-NXF1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, human, rabbit, rat
Application
immunohistochemistry
western blot
western blot
Anti-TAP antibody, Mouse monoclonal, clone 53H8, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
Anti-NXF1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot