PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
Synonyms:
CGPR-A, PDEA, RP43
Species:
Human PDE6A (5145), Mouse Pde6a (225600), Rat Pde6a (307401), sheep PDE6A (101122024), dog PDE6A (403620), cow PDE6A (281973), domestic guinea pig Pde6a (100725241), Zebrafish pde6a (368410), domestic cat PDE6A (101085100), Domestic Rabbit PDE6A (100342363)
UniProtKB ID:
Gene ID:
- Human(5145) Summary: This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
- Mouse(225600) phosphodiesterase 6A, cGMP-specific, rod, alpha
- Rat(307401) phosphodiesterase 6A, cGMP-specific, rod, alpha
- sheep(101122024) phosphodiesterase 6A, cGMP-specific, rod, alpha
- dog(403620) phosphodiesterase 6A, cGMP-specific, rod, alpha
- cow(281973) phosphodiesterase 6A, cGMP-specific, rod, alpha
- domestic guinea pig(100725241) phosphodiesterase 6A, cGMP-specific, rod, alpha
- Zebrafish(368410) phosphodiesterase 6A, cGMP-specific, rod, alpha
- domestic cat(101085100) phosphodiesterase 6A, cGMP-specific, rod, alpha
- Domestic Rabbit(100342363) phosphodiesterase 6A, cGMP-specific, rod, alpha
- naked mole-rat(101718823) phosphodiesterase 6A, cGMP-specific, rod, alpha
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PDE6A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-PDE6A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-PDE6a Antibody, clone 7A11.1, clone 7A11.1, from mouse,
Species Reactivity
human
Application
western blot
Anti-Phosphodiesterase 6α antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
bovine, sheep
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Dipyridamole for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
esiRNA
Product Number
Description
Species