PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
Synonyms:
B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12
Species:
Human PPP2R2B (5521), Mouse Ppp2r2b (72930), Rat Ppp2r2b (60660), cow PPP2R2B (509290), domestic guinea pig Ppp2r2b (100716856), naked mole-rat Ppp2r2b (101700573), dog PPP2R2B (478053), Horse PPP2R2B (100060957), Domestic Rabbit PPP2R2B (100009139), domestic cat PPP2R2B (101084083) ...More
UniProtKB ID:
Gene ID:
- Human(5521) Summary: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]
- Mouse(72930) protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
- Rat(60660) protein phosphatase 2, regulatory subunit B, beta
- cow(509290) protein phosphatase 2, regulatory subunit B, beta
- domestic guinea pig(100716856) protein phosphatase 2, regulatory subunit B, beta
- naked mole-rat(101700573) protein phosphatase 2, regulatory subunit B, beta
- dog(478053) protein phosphatase 2, regulatory subunit B, beta
- Horse(100060957) protein phosphatase 2, regulatory subunit B, beta
- Domestic Rabbit(100009139) protein phosphatase 2, regulatory subunit B, beta
- domestic cat(101084083) protein phosphatase 2, regulatory subunit B, beta
- sheep(101113409) protein phosphatase 2, regulatory subunit B, beta
- chicken(416350) protein phosphatase 2, regulatory subunit B, beta
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PPP2R2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-PPP2R2B antibody produced in mouse, clone 1F3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Monoclonal Anti-PPP2R2B antibody produced in mouse, clone 1B10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
immunoprecipitation (IP)
Anti-PPP2R2B antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Anti-PPP2R2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
esiRNA
Product Number
Description
Species