PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Synonyms:
IFI5111, PA28A, PA28alpha, REGalpha
Species:
Human PSME1 (5720), Mouse Psme1 (19186), Rat Psme1 (29630), domestic guinea pig Psme1 (100735672), naked mole-rat Psme1 (101703339), sheep PSME1 (101117421), dog PSME1 (480256), cow PSME1 (510041), Zebrafish psme1 (30648), domestic cat PSME1 (101099973)
UniProtKB ID:
Gene ID:
- Human(5720) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(19186) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- Rat(29630) proteasome (prosome, macropain) activator subunit 1
- domestic guinea pig(100735672) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- naked mole-rat(101703339) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- sheep(101117421) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- dog(480256) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- cow(510041) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
- Zebrafish(30648) proteasome activator subunit 1
- domestic cat(101099973) proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSME1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-PSME1 (Isoform 1) antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
western blot
western blot
Anti-PSME1 Antibody, clone 6H7X3, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Anti-PSME1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-PSME1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
esiRNA
Product Number
Description
Species