PTPN11
protein tyrosine phosphatase, non-receptor type 11
Synonyms:
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
Species:
Human PTPN11 (5781), Mouse Ptpn11 (19247), Rat Ptpn11 (25622), sheep PTPN11 (101114308), naked mole-rat Ptpn11 (101701336), dog PTPN11 (477488), domestic cat PTPN11 (101085500), chicken PTPN11 (395815), Horse PTPN11 (100056857), cow PTPN11 (533590)
UniProtKB ID:
Gene ID:
- Human(5781) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
- Mouse(19247) protein tyrosine phosphatase, non-receptor type 11
- Rat(25622) protein tyrosine phosphatase, non-receptor type 11
- sheep(101114308) protein tyrosine phosphatase, non-receptor type 11
- naked mole-rat(101701336) protein tyrosine phosphatase, non-receptor type 11
- dog(477488) protein tyrosine phosphatase, non-receptor type 11
- domestic cat(101085500) protein tyrosine phosphatase, non-receptor type 11
- chicken(395815) protein tyrosine phosphatase, non-receptor type 11
- Horse(100056857) protein tyrosine phosphatase, non-receptor type 11
- cow(533590) protein tyrosine phosphatase, non-receptor type 11
- domestic guinea pig(100732797) protein tyrosine phosphatase, non-receptor type 11
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti- pTyr580 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
Anti-PTPN11 (AB1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-PTPN11 (AB2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SHP2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SH-PTP2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
Description
Species