SESN1
sestrin 1
Synonyms:
PA26, SEST1
Species:
Human SESN1 (27244), Mouse Sesn1 (140742), Rat Sesn1 (294518), domestic cat SESN1 (101099380), cow SESN1 (538226), sheep SESN1 (101115970), dog SESN1 (481956), Zebrafish sesn1 (436933), naked mole-rat Sesn1 (101699483), chicken SESN1 (421766)
UniProtKB ID:
Gene ID:
- Human(27244) Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
- Mouse(140742) sestrin 1
- Rat(294518) sestrin 1
- domestic cat(101099380) sestrin 1
- cow(538226) sestrin 1
- sheep(101115970) sestrin 1
- dog(481956) sestrin 1
- Zebrafish(436933) sestrin 1
- naked mole-rat(101699483) sestrin 1
- chicken(421766) sestrin 1
- domestic guinea pig(100713452) sestrin 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SESN1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-SESN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-sestrin 1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-SESN1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Proteins
Product Number
Description
Species
Sestrin 1 human, recombinant, expressed in baculovirus infected Sf9 cells, ≥44% (SDS-PAGE),
Species
human