SPAG8
sperm associated antigen 8
Synonyms:
BS-84, HSD-1, SMP1, SPAG3, hSMP-1
Species:
Human SPAG8 (26206), Mouse Spag8 (433700), Rat Spag8 (362508), domestic cat SPAG8 (101088033), Horse SPAG8 (100067719), dog SPAG8 (611954), naked mole-rat Spag8 (101712976), domestic guinea pig Spag8 (101787578), sheep SPAG8 (101113200), cow SPAG8 (514627)
UniProtKB ID:
Gene ID:
- Human(26206) Summary: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. This protein interacts with ACT (activator of CREM in testis) and may play a role in CREM (cAMP response element modulator)-ACT-mediated gene transcription during spermatogenesis. This protein may also play a role in spermatogenesis by regulating microtubule formation and cell division. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. [provided by RefSeq, Jul 2012]
- Mouse(433700) sperm associated antigen 8
- Rat(362508) sperm associated antigen 8
- domestic cat(101088033) sperm associated antigen 8
- Horse(100067719) sperm associated antigen 8
- dog(611954) sperm associated antigen 8
- naked mole-rat(101712976) sperm associated antigen 8
- domestic guinea pig(101787578) sperm associated antigen 8
- sheep(101113200) sperm associated antigen 8
- cow(514627) sperm associated antigen 8
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SPAG8 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-SPAG8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-SPAG8 antibody produced in mouse, clone 2F12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
esiRNA
Product Number
Description
Species