SPPL2B
signal peptide peptidase like 2B
Synonyms:
IMP-4, IMP4, PSH4, PSL1
Species:
Human SPPL2B (56928), Mouse Sppl2b (73218), Rat Sppl2b (362828), sheep SPPL2B (101120828), domestic guinea pig Sppl2b (100719910), naked mole-rat Sppl2b (101708060), chicken SPPL2B (420056), dog SPPL2B (485071), domestic cat SPPL2B (101081277), cow SPPL2B (504285)
UniProtKB ID:
Gene ID:
- Human(56928) Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(73218) signal peptide peptidase like 2B
- Rat(362828) signal peptide peptidase-like 2B
- sheep(101120828) signal peptide peptidase like 2B
- domestic guinea pig(100719910) signal peptide peptidase like 2B
- naked mole-rat(101708060) signal peptide peptidase like 2B
- chicken(420056) signal peptide peptidase like 2B
- dog(485071) signal peptide peptidase like 2B
- domestic cat(101081277) signal peptide peptidase like 2B
- cow(504285) signal peptide peptidase-like 2B
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SPPL2B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-SPPL2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot