TERT
telomerase reverse transcriptase
Synonyms:
CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
Species:
Human TERT (7015), Mouse Tert (21752), Rat Tert (301965), domestic guinea pig Tert (100732437), chicken TERT (420972), Zebrafish tert (796551), naked mole-rat Tert (101706965), domestic cat TERT (100144612), cow TERT (518884), sheep TERT (100126866) ...More
UniProtKB ID:
Gene ID:
- Human(7015) Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
- Mouse(21752) telomerase reverse transcriptase
- Rat(301965) telomerase reverse transcriptase
- domestic guinea pig(100732437) telomerase reverse transcriptase
- chicken(420972) telomerase reverse transcriptase
- Zebrafish(796551) telomerase reverse transcriptase
- naked mole-rat(101706965) telomerase reverse transcriptase
- domestic cat(100144612) telomerase reverse transcriptase
- cow(518884) telomerase reverse transcriptase
- sheep(100126866) telomerase reverse transcriptase
- sheep(101112422) telomerase reverse transcriptase
- dog(403412) telomerase reverse transcriptase
- Thale Cress(831548) telomerase reverse transcriptase
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-Telomerase (pSer824) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-TERT antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-TERT (human) Antibody, clone 2C4, clone 2C4, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-TERT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-Telomerase antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunofluorescence
Small Molecule - Inhibitor
Product Number
Description
Species
esiRNA
Product Number
Description
Species