TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
別名:
APO2L, Apo-2L, CD253, TL2, TRAIL
Species:
Human TNFSF10 (8743), Mouse Tnfsf10 (22035), Rat Tnfsf10 (246775), naked mole-rat Tnfsf10 (101702439), domestic guinea pig Tnfsf10 (100734497), cow TNFSF10 (507215), sheep TNFSF10 (101114153), domestic cat TNFSF10 (101083289), domestic cat TNFSF10 (100174789), dog TNFSF10 (100174780) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(8743) Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Mouse(22035) tumor necrosis factor (ligand) superfamily, member 10
- Rat(246775) tumor necrosis factor (ligand) superfamily, member 10
- naked mole-rat(101702439) tumor necrosis factor (ligand) superfamily, member 10
- domestic guinea pig(100734497) tumor necrosis factor (ligand) superfamily, member 10
- cow(507215) tumor necrosis factor (ligand) superfamily, member 10
- sheep(101114153) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(101083289) tumor necrosis factor (ligand) superfamily, member 10
- domestic cat(100174789) tumor necrosis factor (ligand) superfamily, member 10
- dog(100174780) tumor necrosis factor (ligand) superfamily, member 10
- Zebrafish(436866) tumor necrosis factor (ligand) superfamily, member 10
- chicken(378894) tumor necrosis factor (ligand) superfamily, member 10
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ELISA
Antibodies
製品番号
詳細
交差性
アプリケーション
Anti-TRAIL/CD253 Antibody, clone 6D12.2, clone 6D12.2, from mouse,
交差性
human
アプリケーション
flow cytometry
immunohistochemistry
immunohistochemistry
Anti-TNFSF10 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-sTRAIL Antibody, clone III6F, clone III6F, from mouse,
交差性
human
アプリケーション
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
immunohistochemistry
immunoprecipitation (IP)
Monoclonal Anti-CD253-APC antibody produced in mouse, clone 2E5,
交差性
アプリケーション
flow cytometry
Monoclonal Anti-CD253 antibody produced in mouse, clone 2E5,
交差性
human
アプリケーション
flow cytometry
Proteins
製品番号
詳細
Species
TRAILタンパク質、リコンビナントヒト, Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.,
Species
human
TRAIL ヒト, recombinant, expressed in E. coli, ≥98% (SDS-PAGE and HPLC), lyophilized powder,
Species
human
TRAIL, Soluble human, recombinant, expressed in E. coli, His tagged, >98% (SDS-PAGE),
Species
human
TRAIL, Soluble mouse, recombinant, expressed in E. coli, His tagged, >95% (SDS-PAGE),
Species
mouse
TRAIL マウス由来, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
mouse