UBE2D1
ubiquitin-conjugating enzyme E2D 1
Synonyms:
E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
Species:
Human UBE2D1 (7321), Mouse Ube2d1 (216080), Rat Ube2d1 (361831), chicken UBE2D1 (423641), Goat UBE2D1 (100861089), cow UBE2D1 (535287), Horse UBE2D1 (100062598), naked mole-rat Ube2d1 (101698794), domestic guinea pig Ube2d1 (100734273), sheep UBE2D1 (101120209)
UniProtKB ID:
Gene ID:
- Human(7321) Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
- Mouse(216080) ubiquitin-conjugating enzyme E2D 1
- Rat(361831) ubiquitin-conjugating enzyme E2D 1
- chicken(423641) ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
- Goat(100861089) ubiquitin-conjugating enzyme E2D 1
- cow(535287) ubiquitin-conjugating enzyme E2D 1
- Horse(100062598) ubiquitin-conjugating enzyme E2D 1
- naked mole-rat(101698794) ubiquitin-conjugating enzyme E2D 1
- domestic guinea pig(100734273) ubiquitin-conjugating enzyme E2D 1
- sheep(101120209) ubiquitin-conjugating enzyme E2D 1
- dog(608578) ubiquitin-conjugating enzyme E2D 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-UBE2D1 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, goat, horse, human, mouse, pig, rat
Application
western blot
Monoclonal Anti-UBE2D1 antibody produced in mouse, clone 2C6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-UBE2D1/UbcH5 Antibody, clone 1F22 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot