Skip to Content
MilliporeSigma

UCP1

uncoupling protein 1 (mitochondrial, proton carrier)

Synonyms:
SLC25A7, UCP
Species:
UniProtKB ID:
Gene ID:
  • Human(7350) Summary: Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
  • Mouse(22227) uncoupling protein 1 (mitochondrial, proton carrier)
  • Rat(24860) uncoupling protein 1 (mitochondrial, proton carrier)
  • dog(403574) uncoupling protein 1 (mitochondrial, proton carrier)
  • domestic guinea pig(100722020) uncoupling protein 1 (mitochondrial, proton carrier)
  • Zebrafish(83908) uncoupling protein 1
  • Domestic Rabbit(100328618) uncoupling protein 1 (mitochondrial, proton carrier)
  • domestic cat(101089511) uncoupling protein 1 (mitochondrial, proton carrier)
  • naked mole-rat(101723752) uncoupling protein 1 (mitochondrial, proton carrier)
  • cow(281561) uncoupling protein 1 (mitochondrial, proton carrier)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-UCP1 antibody produced in mouse, clone 4E5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-Uncoupling Protein 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
Anti-Uncoupling Protein 1 Antibody, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
Anti-UCP1+UCP3 Antibody, clone 0S10O10, Rabbit Monoclonal, ,
Species Reactivity
mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-UCP1 antibody produced in mouse, clone 4B7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot

Proteins

Product Number
Description
Species
Uncoupling Protein 1, control peptide for AB3038, ,
Species
rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human UCP1,
Species
human