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VRK1

vaccinia related kinase 1

Synonyms:
PCH1, PCH1A
Species:
UniProtKB ID:
Gene ID:
  • Human(7443) Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
  • Mouse(22367) vaccinia related kinase 1
  • Rat(362779) vaccinia related kinase 1
  • domestic guinea pig(100728382) vaccinia related kinase 1
  • naked mole-rat(101713744) vaccinia related kinase 1
  • chicken(423443) vaccinia related kinase 1
  • Zebrafish(406694) vaccinia related kinase 1
  • dog(490848) vaccinia related kinase 1
  • domestic cat(101091879) vaccinia related kinase 1
  • cow(618880) vaccinia related kinase 1
  • sheep(101122310) vaccinia related kinase 1

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-VRK1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-Vaccinia related kinase-1 Antibody, N-Terminus, from rabbit,
Species Reactivity
human
Application
ELISA
western blot
Monoclonal Anti-VRK1 antibody produced in mouse, clone 4F9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

immunoprecipitation (IP)

western blot
Anti-Vaccinia related kinase-1 Antibody, C-Terminus, from rabbit,
Species Reactivity
human
Application
ChIP
western blot

Proteins

Product Number
Description
Species
VRK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Vrk1,
Species
mouse
MISSION® esiRNA, targeting human VRK1,
Species
human