XBP1
X-box binding protein 1
Synonyms:
TREB5, XBP-1, XBP2
Species:
Human XBP1 (7494), Mouse Xbp1 (22433), Rat Xbp1 (289754), Zebrafish xbp1 (140614), fruit fly Xbp1 (44226), chicken XBP1 (416918), dog XBP1 (477532), cow XBP1 (541236)
UniProtKB ID:
Gene ID:
- Human(7494) Summary: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
- Mouse(22433) X-box binding protein 1
- Rat(289754) X-box binding protein 1
- Zebrafish(140614) X-box binding protein 1
- fruit fly(44226) X box binding protein-1
- chicken(416918) X-box binding protein 1
- dog(477532) X-box binding protein 1
- cow(541236) X-box binding protein 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-XBP1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human
Application
western blot
Anti-XBP-1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-XBP1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-XBP1 antibody produced in mouse, clone 2D9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-XBP-1 antibody produced in mouse, clone 3H1G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunocytochemistry
western blot
immunocytochemistry
western blot