ZP3
zona pellucida glycoprotein 3 (sperm receptor)
Synonyms:
ZP3A, ZP3B, ZPC, Zp-3
Species:
Human ZP3 (7784), Mouse Zp3 (22788), Rat Zp3 (114639), domestic guinea pig Zp3 (100729911), naked mole-rat Zp3 (101717140), Zebrafish zp3 (30594), chicken ZP3 (378906), dog ZP3 (403894), domestic cat ZP3 (493925), cow ZP3 (280964) ...More
UniProtKB ID:
Gene ID:
- Human(7784) Summary: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
- Mouse(22788) zona pellucida glycoprotein 3
- Rat(114639) zona pellucida glycoprotein 3 (sperm receptor)
- domestic guinea pig(100729911) zona pellucida glycoprotein 3 (sperm receptor)
- naked mole-rat(101717140) zona pellucida glycoprotein 3 (sperm receptor)
- Zebrafish(30594) zona pellucida glycoprotein 3
- chicken(378906) zona pellucida sperm-binding protein 3
- dog(403894) zona pellucida glycoprotein 3 (sperm receptor)
- domestic cat(493925) zona pellucida glycoprotein 3 (sperm receptor)
- cow(280964) zona pellucida glycoprotein 3 (sperm receptor)
- sheep(101118580) zona pellucida glycoprotein 3 (sperm receptor)
- Domestic Rabbit(100009185) zona pellucida glycoprotein 3 (sperm receptor)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ZP3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, horse, human, rabbit
Application
western blot
Anti-Zp3 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-ZP3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
esiRNA
Product Number
Description
Species