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5.08315

Sigma-Aldrich

KN-93 Phosphate Solution

InSolution, ≥95%, 5 mM aqueous solution, A water-soluble form of the CaM kinase II inhibitor KN-93

Synonym(s):

InSolution KN-93 Phosphate in H2O, 2-(N-(2-Hydroxyethyl))-N-(4-methoxybenzenesulfonyl))amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), Phosphate, ( E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, Phosphate

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About This Item

Empirical Formula (Hill Notation):
C26H29ClN2O4S · xH3PO4
Molecular Weight:
501.04
UNSPSC Code:
12352200

Quality Level

100

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
protect from light

storage temp.

−70°C

General description

A water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
CaM kinase II
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 5 mM (500 µg/167 µL) sterile-filtered solution of KN-93 Phosphate (Cat. No. 422711) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Tombes, R.M., et al. 1995. Cell Growth Differ.6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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