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G0419

Sigma-Aldrich

GR 55562 dihydrobromide

>97% (HPLC), powder

Synonym(s):

3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
172854-55-6
Molecular Weight:
537.29
MDL number:
MFCD06201848
UNSPSC Code:
12352202
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description

Store tightly sealed with desiccant.

Assay

>97% (HPLC)

form

powder

color

light yellow

solubility

H2O: ~12 mg/mL (with mixing)

storage temp.

2-8°C

InChI

1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H

InChI key

NUDSRNNZTVHCKY-UHFFFAOYSA-N

Biochem/physiol Actions

5-HT1B/5-HT1D serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
093K4623

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Zheng-Ming Ding et al.
Psychopharmacology, 204(3), 381-390 (2009-01-24)
Previous studies indicated that ethanol could be self-infused into the posterior ventral tegmental area (p-VTA) and that activation of local serotonin-3 (5-HT(3)) receptors was involved. 5-HT(1B) and 5-HT(2A) receptors are involved in the effects of 5-HT and ethanol on VTA
Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14(3), 217-225 (2004-04-02)
The present study was aimed at finding out whether 5-HT(1B) receptors located in the ventral tegmental area (VTA) played a role in the locomotor hyperactivity induced by a single dose of cocaine and in the sensitization evoked by repeated exposure
Iwona Papla et al.
Polish journal of pharmacology, 54(4), 351-357 (2003-01-14)
Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study
Ji-Hyun Kim et al.
Pharmacology, biochemistry, and behavior, 87(1), 41-47 (2007-05-05)
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h
E Przegaliński et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 53(3), 383-394 (2002-10-09)
The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted
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