Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

G0419

Sigma-Aldrich

GR 55562 dihydrobromide

>97% (HPLC), powder

Synonym(s):

3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
172854-55-6
Molecular Weight:
537.29
MDL number:
MFCD06201848
UNSPSC Code:
12352202

description

Store tightly sealed with desiccant.

assay

>97% (HPLC)

form

powder

color

light yellow

solubility

H2O: ~12 mg/mL (with mixing)

storage temp.

2-8°C

InChI

1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H

InChI key

NUDSRNNZTVHCKY-UHFFFAOYSA-N

Biochem/physiol Actions

5-HT1B/5-HT1D serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
093K4623

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 14(3), 217-225 (2004-04-02)
The present study was aimed at finding out whether 5-HT(1B) receptors located in the ventral tegmental area (VTA) played a role in the locomotor hyperactivity induced by a single dose of cocaine and in the sensitization evoked by repeated exposure
Zheng-Ming Ding et al.
Psychopharmacology, 204(3), 381-390 (2009-01-24)
Previous studies indicated that ethanol could be self-infused into the posterior ventral tegmental area (p-VTA) and that activation of local serotonin-3 (5-HT(3)) receptors was involved. 5-HT(1B) and 5-HT(2A) receptors are involved in the effects of 5-HT and ethanol on VTA
Iwona Papla et al.
Polish journal of pharmacology, 54(4), 351-357 (2003-01-14)
Previous research demonstrated that the mesoaccumbens dopamine (DA) pathway played a critical role in the behavioral effects of amphetamine in rodents. Nonetheless, recent findings have also indicated involvement of 5-hydroxytryptamine (5-HT, serotonin) transmission in these effects. In the present study
Małgorzata Filip et al.
Naunyn-Schmiedeberg's archives of pharmacology, 366(3), 226-234 (2002-08-13)
Recent data indicate a significant input of serotonin (5-HT) on mesoaccumbens dopamine-dependent behavioral effects of cocaine in rats. The present study investigated the role of 5-HT(1B) receptors in nucleus accumbens subregions (the shell and the core) and the effect of
Kayi Y Chan et al.
European journal of pharmacology, 619(1-3), 61-67 (2009-07-22)
Tegaserod, a 5-HT(4) receptor agonist, has been used to treat idiopathic constipation and constipation-predominant irritable bowel disease. It has recently been suggested that tegaserod has an affinity for 5-HT(1B) receptors, which mediate vasoconstriction. As some patients have experienced cardiac ischemia
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service