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V0377

Sigma-Aldrich

[Arg8]-Vasopressin solution

Grade VI (synthetic), ~100 IU/mL in 0.9% NaCl

Synonym(s):

β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin

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About This Item

Empirical Formula (Hill Notation):
C46H65N15O12S2
CAS Number:
113-79-1
Molecular Weight:
1084.23
MDL number:
MFCD00076738
UNSPSC Code:
51111800
PubChem Substance ID:
24900692
NACRES:
NA.32
biological source:
synthetic (organic)
form:
liquid

biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

type

Grade VI (synthetic)

form

liquid

contains

0.4% 4-chlorobutanol as preservative

concentration

~100 IU/mL in 0.9% NaCl

pH

~3.5

UniProt accession no.

P01185

shipped in

ambient

Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[Arg8]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.

Biochem/physiol Actions

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.
[Arg8]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
0000341069
SLCL1918
SLCN5672
SLCG7030
SLCF2277

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J J McDonnell et al.
The Anatomical record, 240(4), 528-536 (1994-12-01)
Beta-endorphin and oxytocin immunocytochemical localization were examined in the neurointermediate lobe (lobus nervosus and pars intermedia) of the bovine hypophysis in order to describe the anatomical distribution of these two neurointermediate lobe hormones. Twenty-seven bovine hypophyses were collected from slaughterhouse
Lone Brønd et al.
American journal of physiology. Renal physiology, 305(11), F1547-F1554 (2013-10-04)
A number of studies have shown that rats with congestive heart failure (CHF) have increased protein levels of the vasopressin (AVP)-regulated water channel aquaporin-2 (AQP2) even during conditions with unchanged circulating levels of AVP, suggesting an increase in the sensitivity
Vanessa Vezzi et al.
Scientific reports, 10(1), 9111-9111 (2020-06-06)
Vasopressin receptor 2 (V2R) mutations causing the nephrogenic syndrome of inappropriate antidiuresis (NSIAD) can generate two constitutively active receptor phenotypes. One type results from residue substitutions in several V2R domains and is sensitive to vaptan inverse agonists. The other is
Daniel J van Wamelen et al.
Sleep, 36(1), 117-125 (2013-01-05)
To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex
David E Lanfear et al.
Circulation. Heart failure, 6(1), 47-52 (2012-12-15)
Arginine vasopressin (AVP) levels are elevated in proportion to heart failure severity and are associated with higher cardiovascular mortality in ambulatory patients. However, the relationship between baseline and trends in AVP with outcomes in patients hospitalized for worsening heart failure
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