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O6379

Sigma-Aldrich

Oxytocin acetate salt hydrate

≥97% (HPLC)

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Synonym(s):
α-Hypophamine
Empirical Formula (Hill Notation):
C43H66N12O12S2
CAS Number:
Molecular Weight:
1007.19
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic (organic)

Quality Level

sterility

non-sterile

Assay

≥97% (HPLC)

form

powder

solubility

water: 10 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)

InChI key

XNOPRXBHLZRZKH-UHFFFAOYSA-N

Gene Information

human ... OXT(5020)

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This Item
O3251O4375V9879
Oxytocin

Sigma-Aldrich

O3251

Oxytocin

Oxytocin lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

Sigma-Aldrich

O4375

Oxytocin

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

-

assay

≥95% (HPLC)

form

powder

form

lyophilized powder

form

lyophilized powder

form

powder

solubility

water: 10 mg/mL, clear, colorless

solubility

-

solubility

water: 10 mg/mL, clear, colorless

solubility

water: 20.0-20.8 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns, where first exon codes for hormone OXT while other exon codes for neurophysin I.

Application

Oxytocin acetate salt hydrate has been used in cell proliferation assay and is used in experiments to study the effect of oxytocin in the prelimbic (PL) region of the medial prefrontal cortex (mPFC) on anxiety. It is used as a marker in receptor autoradiography to assess nonspecific tissue binding in the periphery of the neonatal mouse.

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders, and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).
Stimulates uterine contraction and lactation; increases Na+ excretion; stimulates myometrial GTPase and phospholipase C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Paloma P Maldonado et al.
Current biology : CB, 31(2), 322-333 (2020-11-07)
Spontaneous network activity shapes emerging neuronal circuits during early brain development prior to sensory perception. However, how neuromodulation influences this activity is not fully understood. Here, we report that the neuromodulator oxytocin differentially shapes spontaneous activity patterns across sensory cortices.
Dara K Shahrokh et al.
Endocrinology, 151(5), 2276-2286 (2010-03-17)
Variations in maternal behavior among lactating rats associate with differences in estrogen-oxytocin interactions in the medial preoptic area (mPOA) and in dopamine levels in the nucleus accumbens (nAcc). Thus, stable, individual differences in pup licking/grooming (LG) are abolished by oxytocin
Oxytocin receptor binding sites in the periphery of the neonatal mouse.
Greenwood MA
PLoS ONE, 12(2), e0172904-e0172904 (2017)
Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat.
Shahrokh DK
Endocrinology, 151(5), 2276-2286 (2010)
Sara Sabihi et al.
Psychoneuroendocrinology, 45, 31-42 (2014-05-23)
The neuropeptide oxytocin (OT) is anxiolytic in rodents and humans. However, the specific brain regions where OT acts to regulate anxiety requires further investigation. The medial prefrontal cortex (mPFC) has been shown to play a role in the modulation of

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