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Safety Information

SRP3279

Sigma-Aldrich

BMP-5 human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):

none

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5 G
$307.80

$307.80

List Price$324.00

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5 G
$307.80

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

$307.80

List Price$324.00

In StockDetails

biological source

human

recombinant

expressed in CHO cells

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

potency

0.5-1.0 μg/mL ED50

mol wt

31.2 kDa

packaging

pkg of 10 μg

impurities

<0.1 EU/μg endotoxin, tested

color

white to off-white

UniProt accession no.

P22003

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Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 10,000

724459

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 5,000

724807

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 2,000

724815

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated average Mn 2,000

725668

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated

mp

>300 °C

mp

>300 °C

mp

>300 °C

mp

>300 °C

mol wt

average Mn 10,000 by GPC (THF w/ 5%TEA, PS, RI)

mol wt

average Mn 5,000

mol wt

average Mn 2,000

mol wt

average Mn 2,000

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs.

Biochem/physiol Actions

TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. BMP-5 is expressed in the nervous system, lung and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant human BMP-5 is a 15.6 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.

Physical form

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP3279-10UG:

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0112549

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    Di Chen et al.
    Growth factors (Chur, Switzerland), 22(4), 233-241 (2004-12-29)
    Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years.
    Elina V García et al.
    Theriogenology, 84(4), 589-599 (2015-05-28)
    Previous studies have reported that bone morphogenetic protein 5 (BMP5) is differentially expressed in the isthmus of bovine oviducts and it is present in the oviductal fluid. However, the specific action of this factor is unknown. To evaluate whether BMP5

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