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724459

Sigma-Aldrich

Poly(N-isopropylacrylamide), carboxylic acid terminated

average Mn 10,000

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Synonym(s):
NIPAM polymer, PNIPAM-COOH, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
Linear Formula:
(C6H11NO)nSCH2CH2CO2H
NACRES:
NA.23

form

powder

Quality Level

100

mol wt

average Mn 10,000 by GPC (THF w/ 5%TEA, PS, RI)
average Mn 10,000

mp

>300 °C

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This Item
724815725668724831
Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 10,000

Sigma-Aldrich

724459

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), carboxylic acid terminated average Mn 2,000

Sigma-Aldrich

724815

Poly(N-isopropylacrylamide), carboxylic acid terminated

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated average Mn 2,000

Sigma-Aldrich

725668

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated

Poly(N-isopropylacrylamide), amine terminated average Mn 5,500 (T)

Sigma-Aldrich

724831

Poly(N-isopropylacrylamide), amine terminated

mp

>300 °C

mp

>300 °C

mp

>300 °C

mp

-

mol wt

average Mn 10,000 by GPC (THF w/ 5%TEA, PS, RI)

mol wt

average Mn 2,000

mol wt

average Mn 2,000

mol wt

average Mn 5,500 (HCl titration)

Application

PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering
Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Aniket S Wadajkar et al.
Acta biomaterialia, 8(8), 2996-3004 (2012-05-09)
New magnetic-based core-shell particles (MBCSPs) were developed to target skin cancer cells while delivering chemotherapeutic drugs in a controlled fashion. MBCSPs consist of a thermo-responsive shell of poly(N-isopropylacrylamide-acrylamide-allylamine) and a core of poly(lactic-co-glycolic acid) (PLGA) embedded with magnetite nanoparticles. To
Chenglin Yi et al.
Journal of colloid and interface science, 380(1), 90-98 (2012-05-29)
Self-assembled polymeric micelles can be used as efficient particulate emulsifiers. To explore the relationship between micellar structure and emulsification performance, pH- and temperature-responsive self-assembled micelles were prepared and used as emulsifiers, based on a novel grafted polymer poly(styrene-alt-maleic acid)-graft-poly(N-isopropyl acrylamide)
Yan Xia et al.
Chemical communications (Cambridge, England), 49(25), 2566-2568 (2013-02-21)
Site-specific protein conjugates with RAFT polymers were synthesized using expressed protein ligation. Stable micelles were formed from both linear block copolymer and Y-shaped conjugates.
Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with
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Articles

Designing Temperature and pH Sensitive NIPAM Based Polymers

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

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