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Sigma-Aldrich

Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated

average Mn 2,000

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Synonym(s):
NIPAM polymer, PNIPAM-NHS, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
Linear Formula:
(C6H11NO)n SCH2CH2COO(C4H4NO2)
NACRES:
NA.23

form

powder

mol wt

average Mn 2,000

mp

>300 °C

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724815724823747068
mp

>300 °C

mp

>300 °C

mp

-

mp

-

mol wt

average Mn 2,000

mol wt

average Mn 2,000

mol wt

Mn 2000-3000 (by HCL Titration)

mol wt

average Mn 15,000

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Novel polymer for development of thermosensitive coated micro/nano materialincluding thermoresponsive polymeric drug delivery systems. The NHS ester functional group can be used to conjugate a variety of biomolecules such as enzymes† to the polymer chain.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Sigma-Aldrich

JKA5021

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Rzaev, Z.M.O.; Dincer, S.; Piskin, E.
Progress in Polymer Science, 32, 534-534 (2007)
Chung, J. E.; Yokoyama, M.; Suzuki, K.; Aoyagi, T.; Sakurai, Y.; Okano, T.
Colloids and Surfaces, B: Biointerfaces, 9, 37-37 (1997)
K Fujimoto et al.
Biomacromolecules, 1(4), 515-518 (2001-11-17)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in

Articles

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.

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