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900188

Sigma-Aldrich

Poly(N-isopropyl acrylamide)

NHS ester end functionalized, average Mn 5,000

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Synonym(s):
PNIPAM, polyNIPAM
Linear Formula:
C8H10NO4(C6H11NO)nH
NACRES:
NA.23

Quality Level

form

solid

mol wt

average Mn 5,000

storage temp.

2-8°C

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This Item
806366747068762857
Poly(N-isopropyl acrylamide) NHS ester end functionalized, average Mn 5,000

900188

Poly(N-isopropyl acrylamide)

Poly(N-isopropyl acrylamide) carboxylic acid, thiol

806366

Poly(N-isopropyl acrylamide)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

mol wt

average Mn 5,000

mol wt

Mn 6,000

mol wt

average Mn 15,000

mol wt

average Mn 30,000

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Poly(N-isopropyl acrylamide) (PolyNIPAM) is a stimuli-responsive polymer. This product features low polydispersity (PDI), which typically leads to better reproducibility in applications, and a terminal N-hydroxysuccinimide (NHS) functional group, allowing for rapid conjugation of biomolecules, small molecules, or other polymers. PolyNIPAM has been used in development of a variety of thermosensitive coated micro/nano materials, including thermoresponsive polymeric drug delivery systems.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Shahrzad Rayatpisheh et al.
Macromolecular bioscience, 12(7), 937-945 (2012-04-27)
A new method for ultrathin grafting of pNIPAm on PDMS surfaces is introduced that employs plasma activation of the surface followed by thermal polymerization. This method is optimized for human primary SMC attachment and subsequent intact cell sheet detachment by
Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with
A C C Rotzetter et al.
Advanced materials (Deerfield Beach, Fla.), 24(39), 5352-5356 (2012-08-31)
Buildings can be effectively cooled by a bioinspired sweating-like action based on thermoresponsive hydrogels (PNIPAM), which press out their stored water when exceeding the lower critical solution temperature. The surface temperature is reduced by 15 °C compared to that of
Tatiya Trongsatitkul et al.
Colloids and surfaces. B, Biointerfaces, 103, 244-252 (2012-12-04)
The effect of PEGylation on the thermal response and protein adsorption resistance of crosslinked PNIPAm microgels was investigated. It was found that the presence of PEG, its molecular weight (M(n) 300 and 1100 g/mol) and its concentration (10, 20, and

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