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S9192

Sigma-Aldrich

Ser-Leu-Ile-Gly-Lys-Val-amide

≥95% (HPLC), solid

Synonym(s):

PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2

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10 MG
$161.00

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Estimated to ship onMarch 23, 2025


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10 MG
$161.00

About This Item

Empirical Formula (Hill Notation):
C28H54N8O7
CAS Number:
Molecular Weight:
614.78
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

$161.00


Estimated to ship onMarch 23, 2025


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Quality Level

assay

≥95% (HPLC)

form

solid

UniProt accession no.

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1

InChI key

HOWDUIVVWDUEED-WAUHAFJUSA-N

Gene Information

mouse ... Insrr(23920)

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This Item
597475568979302
form

crystals, powder

form

powder

form

lyophilized powder

form

crystalline, crystals, powder or flakes

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Amino Acid Sequence

Ser-Leu-Ile-Gly-Lys-Val-NH2

Biochem/physiol Actions

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus.[1] PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.[2]
Proteinase-activated receptor-2 (PAR2)-activating peptide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
Bono F, et al.
Biochemical and Biophysical Research Communications, 241(3), 762-764 (1997)
Kaushik Das et al.
Scientific reports, 8(1), 7357-7357 (2018-05-11)
Metastasis, the hallmark of cancer propagation is attributed by the modification of phenotypic/functional behavior of cells to break attachment and migrate to distant body parts. Cancer cell-secreted microvesicles (MVs) contribute immensely in disease propagation. These nano-vesicles, generated from plasma membrane
D Quanjun et al.
European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)
Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)
Abhishek Roy et al.
The Journal of biological chemistry, 292(33), 13688-13701 (2017-05-20)
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either

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