917222

A1V2PF1-NHEt

≥95%

• 別名: (S)-1-((S)-2-((S)-2-Aminopropanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
• 実験式（ヒル表記法）: C₂₇H₄₁N₅O₄
• 分子量: 499.65
• MDL番号: MFCD33021750
• UNSPSCコード: 41116105
• NACRES: NA.22

特性

• ligand: A1V2PF1
• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder
• 反応適合性: reagent type: ligand
• 官能基: amine
• 保管温度: 2-8°C
• SMILES記法: N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=CC=C2)=O)=O)C3CCCCC3)=O)C
• InChI: 1S/C27H41N5O4/c1-3-29-25(34)21(17-19-11-6-4-7-12-19)30-26(35)22-15-10-16-32(22)27(36)23(31-24(33)18(2)28)20-13-8-5-9-14-20/h4,6-7,11-12,18,20-23H,3,5,8-10,13-17,28H2,1-2H3,(H,29,34)(H,30,35)(H,31,33)/t18-,21-,22-,23-/m0/s1
• InChI Key: OMNNTFDLWROHJN-QGQQZZQASA-N

詳細

アプリケーション

A1V2PF1-NHEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V2PF1-NHEt is also available as BocA1V2PF1 (916978).

A1V2PF1-NHEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks
916943 A1V2PF1-NHEt-C₆-NH₂
917206 A1V2PF1-NHEt-C₁₀-NH₂
917451 A1V2PF1-NHEt-PEG₁-NH₂
917702 A1V2PF1-NHEt-PEG₃-NH₂

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

その他情報

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable