おすすめの製品
品質水準
無菌性
0.2 μm filtered
フォーム
viscous liquid (gel)
不純物
<5 cfu/mL Bioburden
<50 EU/mL Endotoxin
色
pale yellow to colorless
pH
6.5-7.5
粘度
10-40 cP
アプリケーション
3D bioprinting
保管温度
2-8°C
関連するカテゴリー
詳細
Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell-binding motifs, gelatin has become a highly sought material for tissue engineering applications.
Alginate is a naturally occurring polymer widely applied for bioprinting applications as its printability can be easily modified by altering the polymer density and crosslinking with the addition of calcium chloride (CaCl2). Alginate is often combined with gelatin to facilitate cell adhesion and differentiation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
Alginate is a naturally occurring polymer widely applied for bioprinting applications as its printability can be easily modified by altering the polymer density and crosslinking with the addition of calcium chloride (CaCl2). Alginate is often combined with gelatin to facilitate cell adhesion and differentiation.
Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.
アプリケーション
Gelatin methacrylate based bioinks have been used in the following bioprinting applications:
- osteogenic [1],
- chondrogenic [2] [3],
- hepatic [4] [5] [6],
- adipogenic [7],
- vasculogenic [8],
- epithelial [6],
- endothelial [9] [10],
- cardiac valve [11],
- skin [12],
- tumors [10]
特徴および利点
- Ready-to-use formulation optimized for high printing fidelity and cell viability, eliminating the lengthy bioink formulation development process
- Step-by-step protocols developed and tested by MilliporeSigma 3D Bioprinting Scientists, no prior 3D bioprinting experience needed
- Suitable for different extrusion-based 3D bioprinter model
- Methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio.
法的情報
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
10 - Combustible liquids
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
925055-10ML:
925055-BULK:
925055-VAR:
最新バージョンのいずれかを選択してください：
Liliang Ouyang et al.
Biofabrication, 8(3), 035020-035020 (2016-09-17)
3D cell printing is an emerging technology for fabricating complex cell-laden constructs with precise and pre-designed geometry, structure and composition to overcome the limitations of 2D cell culture and conventional tissue engineering scaffold technology. This technology enables spatial manipulation of
Wanjun Liu et al.
Advanced healthcare materials, 6(12) (2017-05-04)
Bioprinting is an emerging technique for the fabrication of 3D cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly
Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering.
Birgit Huber et al.
Journal of biomaterials applications, 30(6), 699-710 (2015-05-29)
In vitro engineering of autologous fatty tissue constructs is still a major challenge for the treatment of congenital deformities, tumor resections or high-graded burns. In this study, we evaluated the suitability of photo-crosslinkable methacrylated gelatin (GM) and mature adipocytes as components
B Duan et al.
Acta biomaterialia, 10(5), 1836-1846 (2013-12-18)
Tissue engineering has great potential to provide a functional de novo living valve replacement, capable of integration with host tissue and growth. Among various valve conduit fabrication techniques, three-dimensional (3-D) bioprinting enables deposition of cells and hydrogels into 3-D constructs
Wanjun Liu et al.
Biofabrication, 10(2), 024102-024102 (2017-11-28)
Bioinks with shear-thinning/rapid solidification properties and strong mechanics are usually needed for the bioprinting of three-dimensional (3D) cell-laden constructs. As such, it remains challenging to generate soft constructs from bioinks at low concentrations that are favorable for cellular activities. Herein
資料
Learn how 3D bioprinting is revolutionizing drug discovery with highly-controllable cell co-culture, printable biomaterials, and its potential to simulate tissues and organs. This review paper also compares 3D bioprinting to other advanced biomimetic techniques such as organoids and organ chips.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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